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Département de Physiologie et de Pharmacologie |
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Département de Physiologie et de Pharmacologie |
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Laboratoire de Pharmacologie Expérimentale
Publications 1996-2001
2001El-Bardai, S., Lyoussi, B., Wibo, M. and Morel, N. (2001) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clin.Exp.Hypertens. 23, 329-343 [abstract]
Festy, F., Lins, L., Peranzi, G., Octave, J.N., Brasseur, R. and Thomas, A. (2001) Is aggregation of beta-amyloid peptides a mis-functioning of a current interaction process? Biochim.Biophys.Acta 1546, 356-364 [abstract]
Grisshammer, R. and Hermans, E. (2001) Functional coupling with Galpha(q) and Galpha(i1) protein subunits promotes high-affinity agonist binding to the neurotensin receptor NTS-1 expressed in Escherichia coli. FEBS Lett. 493, 101-105 [abstract]
Krenek, P., Salomone, S., Kyselovic, J., Wibo, M., Morel, N. and Godfraind, T. (2001) Lacidipine prevents endothelial dysfunction in salt-loaded stroke-prone hypertensive rats. Hypertension 37, 1124-1128 [abstract]
Robinet, E.A, Geurts, M., Maloteaux, J.M. and Pauwels, P.J. (2001) 'Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 RNA in rat striatum as opposed to c-fos mRNA' Neurosci. Lett. 307, 45-48 [abstract]
Page, G., Peeters, M., Najimi, M., Maloteaux, J.M. and Hermans, E. (2001) 'Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes' J.Neurochem. 76, 1282-1290 [abstract]
Najimi, M., Hermans, E., Rostène, W. and Forgez, P. 'Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP 212 cells' Metab. Brain Dis., in press (accepted July 2001)
Page, G., Chalon S., Emond P., Maloteaux, J.M. and Hermans, E. Pharmacological characterisation of (E)-N-(3-iodoprop-2-enyl)-2-carbomethoxy-3?-(4’-methylphenyl) nortropane (PE2I) binding to the rat neuronal dopamine transporter expressed in COS cells.’ Neurochem Int. in Press, (accepted July 2001)
Hermans, E. and Challiss R.A.J.(2001) 'Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G protein-coupled receptors’ Biochem. J.. in Press, (accepted August 2001)
Maloteaux, J.M. (2001) Pharmacologie de la nicotine. Louvain Med. 120, S76-S80
2000
Emilien, G., Pochon, M., Caldas, C., Isacson, O. and Maloteaux, J.-M. (2000) Impact of genomics on drug discovery and clinical medicine. Q. J. Med. 93, 391-423
Emilien, G., van-Meurs, W. and Maloteaux, J.M. (2000) The dose-response relationship in phase I clinical trials and beyond: use, meaning, and assessment. Pharmacol. Ther. 88, 33-58
Emilien, G., Beyreuther, K., Masters, C.L. and Maloteaux, J.M. (2000) Prospects for pharmacological intervention in Alzheimer disease. Arch.Neurol. 57, 454-459
Emilien, G., Maloteaux, J.M., Beyreuther, K. and Masters, C.L. (2000) Alzheimer disease: mouse models pave the way for therapeutic opportunities. Arch. Neurol. 57, 176-181
Emilien, G., Maloteaux, J.M., Penasse, C., Goodeve, A. and Casimir, C. (2000) Haemophilias: advances towards genetic engineering replacement therapy. Clin. Lab. Haematol. 22, 313-323
Gailly, P., Najimi, M. and Hermans, E. (2000) Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins. FEBS Lett. 483, 109-113
Ghisdal, P., Gomez, J.P. and Morel, N. (2000) Action of a NO donor on the excitation-contraction pathway activated by noradrenaline in rat superior mesenteric artery. J. Physiol. 522 183-196
Gomez, J.-P., Ghisdal, P. and Morel, N. (2000) Changes in the potassium currents in rat aortic smooth muscle cells during postnatal development. Pflügers Arch.- Eur. J. Physiol. 441, 388-397
Hermans, E., Saunders, R., Selkirk, J.V., Mistry, R., Nahorski, S.R. and Challiss, R.A. (2000) Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells. Mol. Pharmacol. 58, 352-360
Kienlen-Campard, P., Tasiaux, B. and Octave, J.N. (2000) The processing and biological function of the human amyloid precursor protein (APP): lessons from different cellular models. Exp.Gerontol. 35, 843-850
Maloteaux, J.-M. (2000) Les maladies dues aux prions. Louvain Méd. 119, 142-148
Mbongolo Mbella, E.G., Bertrand, S., Huez, G. and Octave, J.N. (2000) A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins. Mol. Cell. Biol. 20, 4572-4579
Noel, F., Geurts, M. and Maloteaux, J.M. (2000) Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum. Braz. J. Med. Biol. Res. 33, 237-240
Octave, J.N., Essalmani, R., Tasiaux, B., Menager, J., Czech, C. and Mercken, L. (2000) The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease. J. Biol. Chem. 275, 1525-1528
Page, G., Peeters, M., Maloteaux, J.M. and Hermans, E. (2000) Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. Eur. J. Pharmacol. 403, 75-80
Toussaint, O., Baret, P.V., Brion, J.-P., Cras, P., Collette, F., De Deyn, P.P., Geenen, V., Kienlen-Campard, P., Labeur, C., Legros, J.J., Nève, J., Octave, J.-N., Piérard, G.E., Salmon, E., van den Bosch de Aguilar, P., Van der linden, M., Leuven, F.V. and Vanfleteren, J. (2000) Experimental gerontology in Belgium: from model organisms to age-related pathologies. Exp. Gerontol. 35, 901-906
1999
Brion, J.P., Tremp, G. and Octave, J.N. (1999) Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease. Am. J. Pathol. 154, 255-270
Emilien, G., Maloteaux, J.M., Geurts, M., Hoogenberg, K. and Cragg, S. (1999) Dopamine receptors--physiological understanding to therapeutic intervention potential. Pharmacol. Ther. 84, 133-156
Emilien, G., Maloteaux, J.M. and Ponchon, M. (1999) Pharmacological management of diabetes: recent progress and future perspective in daily drug treatment. Pharmacol. Ther. 81, 37-51
Geurts, M., Hermans, E., Cumps, J. and Maloteaux, J.M. (1999) Dopamine receptor-modulated [35S]GTPgammaS binding in striatum of 6-hydroxydopamine-lesioned rats. Brain Res. 841, 135-142
Geurts, M., Hermans, E. and Maloteaux, J.M. (1999) Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment. Eur. J. Pharmacol. 382, 119-127
Geurts, M., Hermans, E. and Maloteaux, J.M. (1999) Assessment of striatal D1 and D2 dopamine receptor-G protein coupling by agonist-induced [35S]GTP gamma S binding. Life Sci. 65, 1633-1645
Ghisdal, P., Godfraind, T. and Morel, N. (1999) Effect of nitro-L-arginine on electrical and mechanical responses to acetylcholine in the superior mesenteric artery from stroke-prone hypertensive rat. Br. J. Pharmacol. 128, 1513-1523
Kanyonyo, M., Govaerts, S.J., Hermans, E., Poupaert, J.H. and Lambert, D.M. (1999) 3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands. Bioorg. Med. Chem. Lett. 9, 2233-2236
Lambert, D.M., DiPaolo, F.G., Sonveaux, P., Kanyonyo, M., Govaerts, S.J., Hermans, E., Bueb, J., Delzenne, N.M. and Tschirhart, E.J. (1999) Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors. Biochim. Biophys. Acta 1440, 266-274
Massart, P.E., Donckier, J., Kyselovic, J., Godfraind, T., Heyndrickx, G.R. and Wibo, M. (1999) Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding. Hypertension 34, 1197-1201
Mody, N., Hermans, E., Nahorski, S.R. and Challiss, R.A. (1999) Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function. Neuropharmacology 38, 1485-1492
1998
Emilien, G. and Maloteaux, J.M. (1998) Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur. J. Clin. Pharmacol. 53, 389-404
Emilien, G. and Maloteaux, J.M. (1998) Pharmacological management of epilepsy. Mechanism of action, pharmacokinetic drug interactions, and new drug discovery possibilities. Int. J. Clin. Pharmacol. Ther. 36, 181-194
Hermans, E. and Maloteaux, J.M. (1998) Mechanisms of regulation of neurotensin receptors. Pharmacol. Ther. 79, 89-104
Kyselovic, J., Morel, N., Wibo, M. and Godfraind, T. (1998) Prevention of salt-dependent cardiac remodeling and enhanced gene expression in stroke-prone hypertensive rats by the long-acting calcium channel blocker lacidipine. J. Hypertens. 16, 1515-1522
Macq, A.F., Czech, C., Essalmani, R., Brion, J.P., Maron, A., Mercken, L., Pradier, L. and Octave, J.N. (1998) The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes. J. Biol. Chem. 273, 28931-28936
Morel, N., Buryi, V., Feron, O., Gomez, J.P., Christen, M.O. and Godfraind, T. (1998) The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits. Br. J. Pharmacol. 125, 1005-1012
Najimi, M., Souaze, F., Mendez, M., Hermans, E., Berbar, T., Rostene, W. and Forgez, P. (1998) Activation of receptor gene transcription is required to maintain cell sensitization after agonist exposure. Study on neurotensin receptor. J. Biol. Chem. 273, 21634-21641
Salomone, S., Morel, N. and Godfraind, T. (1998) A therapeutic dosage of amlodipine prevents vascular hyporeactivity induced in rats by lipopolysaccharide. Naunyn Schmiedeberg's Arch. Pharmacol. 357, 252-259
Wibo, M., Feron, O., Zheng, L., Maleki, M., Kolar, F. and Godfraind, T. (1998) Thyroid status and postnatal changes in subsarcolemmal distribution and isoform expression of rat cardiac dihydropyridine receptors. Cardiovasc. Res. 37, 151-159
1997
Czech, C., Delaere, P., Macq, A.F., Reibaud, M., Dreisler, S., Touchet, N., Schombert, B., Mazadier, M., Mercken, L., Theisen, M., Pradier, L., Octave, J.N., Beyreuther, K. and Tremp, G. (1997) Proteolytical processing of mutated human amyloid precursor protein in transgenic mice. Brain Res. Mol. Brain Res. 47, 108-116
Godfraind, T., Salomone, S., Morel, N. and Ghisdal, P. (1997) Etude preclinique de l'action d'un anticalcique lors d'un regime riche en sel. [Preclinical study of the action of a calcium channel blocker during salt load]. Bull. Acad. Natl. Med. 181, 289-298
Hermans, E., Geurts, M. and Maloteaux, J.M. (1997) Agonist and antagonist modulation of [35S]-GTP gamma S binding in transfected CHO cells expressing the neurotensin receptor. Br. J. Pharmacol. 121, 1817-1823
Hermans, E., Vanisberg, M.A., Geurts, M. and Maloteaux, J.M. (1997) Down-regulation of neurotensin receptors after ligand-induced internalization in rat primary cultured neurons. Neurochem. Int. 31, 291-299
Jeanjean, A.P., Laterre, E.C. and Maloteaux, J.M. (1997) Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia. Biol. Psychiatry 41, 1010-1019
Knoops, B. and Octave, J.N. (1997) Alpha 1-tubulin mRNA level is increased during neurite outgrowth of NG 108-15 cells but not during neurite outgrowth inhibition by CNS myelin. Neuroreport 8, 795-798
Luabeya, M.K., Vanisberg, M.A., Jeanjean, A.P., Baudhuin, P., Laduron, P.M. and Maloteaux, J.M. (1997) Fractionation of human brain by differential and isopycnic equilibration techniques. Brain Res. Brain Res. Protoc. 1, 83-90
Maron, A., Havaux, N., Le-Roux, A., Knoops, B., Perricaudet, M. and Octave, J.N. (1997) Differential toxicity of ganciclovir for rat neurons and astrocytes in primary culture following adenovirus-mediated transfer of the HSVtk gene. Gene Ther. 4, 25-31
Mottet, I., Demeure, R., Rataud, J., Lucas, M., Wahl, F., Warscotte, V., Thiran, J.P., Goudemant, J.F., Maldague, B., Maloteaux, J.M. and Stutzmann, J.M. (1997) Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study. MAGMA. 5, 185-191
Salomone, S., Morel, N. and Godfraind, T. (1997) Role of nitric oxide in the contractile response to 5-hydroxytryptamine of the basilar artery from Wistar Kyoto and stroke-prone rats. Br. J. Pharmacol. 121, 1051-1058
1996
Emilien, G. and Maloteaux, J.M. (1996) Lithium neurotoxicity at low therapeutic doses Hypotheses for causes and mechanism of action following a retrospective analysis of published case reports. Acta Neurol. Belg. 96, 281-293
Emilien, G., Maloteaux, J.M., Seghers, A. and Charles, G. (1996) Lithium compared to valproic acid and carbamazepine in the treatment of mania: a statistical meta-analysis. Eur. Neuropsychopharmacol. 6, 245-252
Essalmani, R., Macq, A.F., Mercken, L. and Octave, J.N. (1996) Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor. Biochem.Biophys.Res.Commun. 218, 89-96
Essalmani, R., Guillaume, J.M., Mercken, L. and Octave, J.N. (1996) Baculovirus-infected cells do not produce the amyloid peptide of Alzheimer's disease from its precursor. FEBS Lett. 389, 157-161
Gailly, P., Hermans, E. and Gillis, J.M. (1996) Role of [Ca2+]i in "Ca2+ stores depletion-Ca2+ entry coupling' in fibroblasts expressing the rat neurotensin receptor. J. Physiol. 491, -46
Hermans, E., Octave, J.N. and Maloteaux, J.M. (1996) Interaction of the COOH-terminal domain of the neurotensin receptor with a G protein does not control the phospholipase C activation but is involved in the agonist-induced internalization. Mol.Pharmacol. 49, 365-372
Hermans, E. and Maloteaux, J.M. (1996) Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells. Biochem. Pharmacol. 51, 1749-1752
Maron, A., Gustin, T., Le-Roux, A., Mottet, I., Dedieu, J.F., Brion, J.P., Demeure, R., Perricaudet, M. and Octave, J.N. (1996) Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging. Gene Ther. 3, 315-322
Philippe, B., Brion, J.P., Coppens, E. and Octave, J.N. (1996) Generation of a monoclonal antibody to the carboxy-terminal domain of tau by immunization with the amino-terminal domain of the amyloid precursor protein. J. Neurosci. Res. 46, 709-719
Salomone, S., Dessy, C., Morel, N. and Godfraind, T. (1996) Inhibition by bosentan, an endothelin antagonist, of the hypersensitivity to Ca2+ channel activator evoked by salt-loading in basilar artery of stroke-prone spontaneously hypertensive rats. Life Sci. 59, L247-L253
Salomone, S., Silva, C.L., Morel, N. and Godfraind, T. (1996) Facilitation of the vasorelaxant action of calcium antagonists by basal nitric oxide in depolarized artery. Naunyn Schmiedeberg's Arch. Pharmacol. 354, 505-512
Zheng, L., Wibo, M., Kolar, F. and Godfraind, T. (1996) Calcium channels and cation transport ATPases in cardiac hypertrophy induced by aortic constriction in newborn rats. Mol. Cell. Biochem. 163-16423-9, 16423-16429
1995
Buryi, V., Morel, N., Salomone, S., Kerger, S. and Godfraind, T. (1995) Evidence for a direct interaction of thapsigargin with voltage-dependent Ca2+ channel. Naunyn Schmiedeberg's Arch. Pharmacol. 351, 40-45
Emilien, G., Maloteaux, J.M., Seghers, A. and Charles, G. (1995) Lithium therapy in the treatment of manic-depressive illness. Present status and future perspectives. A critical review. Arch. Int. Pharmacodyn. Ther. 330, 251-278
Hermans, E., Gailly, P., Gillis, J.M., Octave, J.N. and Maloteaux, J.M. (1995) Lack of rapid desensitization of Ca2+ responses in transfected CHO cells expressing the rat neurotensin receptor despite agonist-induced internalization. J. Neurochem. 64, 2518-2525
Holemans, S., Feron, O., Octave, J.N. and Maloteaux, J.M. (1995) Interaction of fluorescein derivatives with glibenclamide binding sites in rat brain. Neurosci.Lett. 183, 183-186
Jeanjean, A.P., Moussaoui, S.M., Maloteaux, J.M. and Laduron, P.M. (1995) Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P. Neuroscience 68, 151-157
Maloteaux, J.M., Luabeya, M.K., Vanisberg, M.A., Jeanjean, A.P., Baudhuin, P., Scherman, D. and Laduron, P.M. (1995) Subcellular distribution of receptor sites in human brain: differentiation between heavy and light structures of high and low density. Brain Res. 687, 155-166
Maron, A., Gustin, T., Mottet, I., Demeure, R. and Octave, J.N. (1995) Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance. J. Neurooncol. 24, 259-265
Octave, J.N. (1995) The amyloid peptide and its precursor in Alzheimer's disease. Rev. Neurosci. 6, 287-316
Octave, J.N. (1995) The amyloid peptide precursor in Alzheimer's disease. Acta Neurol. Belg. 95, 197-209
Salomone, S., Morel, N. and Godfraind, T. (1995) Effects of 8-bromo cyclic GMP and verapamil on depolarization-evoked Ca2+ signal and contraction in rat aorta. Br. J. Pharmacol. 114, 1731-1737
Sam, E., Jeanjean, A.P., Maloteaux, J.M. and Verbeke, N. (1995) Apomorphine pharmacokinetics in parkinsonism after intranasal and subcutaneous application. Eur. J. Drug Metab. Pharmacokinet. 20, 27-33
Wibo, M., Kolar, F., Zheng, L. and Godfraind, T. (1995) Influence of thyroid status on postnatal maturation of calcium channels, beta-adrenoceptors and cation transport ATPases in rat ventricular tissue. J. Mol. Cell. Cardiol. 27, 1731-1743