Publications Emmanuel Hermans (updated 15 Jan 2005)

Vermeiren C., Najimi M., Maloteaux J. M. and Hermans E. (2005) Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation. Neurochem. Int. 46, 137-147.

Race V., Marie S., Kienlen-Campard P., Hermans E., Octave J. N., Van den B. G. and Vincent M. F. (2004) Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s). Nucleosides Nucleotides Nucleic Acids 23, 1227-1229.

Govaerts S. J., Hermans E. and Lambert D. M. (2004) Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors. Eur J Pharm. Sci. 23, 233-243.

Vanhoutte N., de Hemptinne., I, Vermeiren C., Maloteaux J. M. and Hermans E. (2004) In vitro differentiated neural stem cells express functional glial glutamate transporters. Neurosci Lett. 370, 230-235.

de Hemptinne., I, Vermeiren C., Maloteaux J. M. and Hermans E. (2004) Induction of glial glutamate transporters in adult mesenchymal stem cells. J Neurochem. 91, 155-166.

Hermans E. (2004) Generation of model cell lines expressing recombinant G-protein-coupled receptors. Methods Mol Biol. 259, 137-153.

Govaerts S. J., Muccioli G. G., Hermans E. and Lambert D. M. (2004) Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors. Eur J Pharmacol 495, 43-53.

Hermans E. and Hermans C. (2004) [Current advances in hemostatic and antithrombotic agents]. J Pharm. Belg. 59, 13-14.

Peeters M., Romieu P., Maurice T., Su T. P., Maloteaux J. M. and Hermans E. (2004) Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine. Eur J Neurosci 19, 2212-2220.

Geurts M., Maloteaux J. M. and Hermans E. (2003) Altered expression of regulators of G-protein signaling (RGS) mRNAs in the striatum of rats undergoing dopamine depletion. Biochem. Pharmacol 66, 1163-1170.

Skrzydelski D., Lhiaubet A. M., Lebeau A., Forgez P., Yamada M., Hermans E., Rostene W. and Pelaprat D. (2003) Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 64, 421-429.

Hermans E. (2003) Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors. Pharmacol Ther. 99, 25-44.

Peeters M., Maloteaux J. M. and Hermans E. (2003) Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum. Neurosci Lett. 343, 205-209.

Geurts M., Hermans E. and Maloteaux J. M. (2002) Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum. Neurosci Lett. 333, 146-150.

Peeters M., Page G., Maloteaux J. M. and Hermans E. (2002) Hypersensitivity of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine. Brain Res. 949, 32-41.

Najimi M., Maloteaux J. M. and Hermans E. (2002) Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. FEBS Lett. 523, 224-228.

Najimi M., Gailly P., Maloteaux J. M. and Hermans E. (2002) Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins. FEBS Lett. 512, 329-333.

Najimi M., Hermans E., Rostene W. and Forgez P. (2001) Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells. Metab Brain Dis. 16, 165-174.

Page G., Chalon S., Emond P., Maloteaux J. M. and Hermans E. (2002) Pharmacological characterisation of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)nortro pane (PE2I) binding to the rat neuronal dopamine transporter expressed in COS cells. Neurochem. Int. 40, 105-113.

Hermans E. and Challiss R. A. (2001) Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem. J 359, 465-484.

Grisshammer R. and Hermans E. (2001) Functional coupling with Galpha(q) and Galpha(i1) protein subunits promotes high-affinity agonist binding to the neurotensin receptor NTS-1 expressed in Escherichia coli. FEBS Lett. 493, 101-105.

Page G., Peeters M., Najimi M., Maloteaux J. M. and Hermans E. (2001) Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. J Neurochem. 76, 1282-1290.

Gailly P., Najimi M. and Hermans E. (2000) Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins. FEBS Lett. 483, 109-113.

Page G., Peeters M., Maloteaux J. M. and Hermans E. (2000) Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. Eur J Pharmacol 403, 75-80.

Hermans E., Saunders R., Selkirk J. V., Mistry R., Nahorski S. R. and Challiss R. A. (2000) Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells. Mol Pharmacol 58, 352-360.

Geurts M., Hermans E. and Maloteaux J. M. (1999) Assessment of striatal D1 and D2 dopamine receptor-G protein coupling by agonist-induced [35S]GTP gamma S binding. Life Sci. 65, 1633-1645.

Geurts M., Hermans E., Cumps J. and Maloteaux J. M. (1999) Dopamine receptor-modulated [35S]GTPgammaS binding in striatum of 6-hydroxydopamine-lesioned rats. Brain Res. 841, 135-142.

Mody N., Hermans E., Nahorski S. R. and Challiss R. A. (1999) Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function. Neuropharmacology 38, 1485-1492.

Geurts M., Hermans E. and Maloteaux J. M. (1999) Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment. Eur J Pharmacol 382, 119-127.

Lambert D. M., DiPaolo F. G., Sonveaux P., Kanyonyo M., Govaerts S. J., Hermans E., Bueb J., Delzenne N. M. and Tschirhart E. J. (1999) Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors. Biochim. Biophys. Acta 1440, 266-274.

Kanyonyo M., Govaerts S. J., Hermans E., Poupaert J. H. and Lambert D. M. (1999) 3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands. Bioorg. Med. Chem. Lett. 9, 2233-2236.

Hermans E., Challiss R. A. and Nahorski S. R. (1999) Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists. Br J Pharmacol 126, 873-882.

Hermans E., Nahorski S. R. and Challiss R. A. (1999) Heterologous mammalian expression systems for investigating the properties of metabotropic glutamate receptors. Biochem. Soc. Trans. 27, 164-170.

Hermans E., Nahorski S. R. and Challiss R. A. (1998) Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor. Neuropharmacology 37, 1645-1647.

Hermans E., Anten H. W., Diederiks J. P. and Philipsen H. (1998) Use of care by home-dwelling stroke patients during three years following hospital discharge. Scand. J Caring Sci. 12, 186-190.

Hermans E. and Maloteaux J. M. (1998) Mechanisms of regulation of neurotensin receptors. Pharmacol Ther. 79, 89-104.

Najimi M., Souaze F., Mendez M., Hermans E., Berbar T., Rostene W. and Forgez P. (1998) Activation of receptor gene transcription is required to maintain cell sensitization after agonist exposure. Study on neurotensin receptor. J Biol. Chem. 273, 21634-21641.

Hermans E., Young K. W., Challiss R. A. and Nahorski S. R. (1998) Effects of human type 1alpha metabotropic glutamate receptor expression level on phosphoinositide and Ca2+ signalling in an inducible cell expression system. J Neurochem. 70, 1772-1775.

Hermans E., Geurts M. and Maloteaux J. M. (1997) Agonist and antagonist modulation of [35S]-GTP gamma S binding in transfected CHO cells expressing the neurotensin receptor. Br J Pharmacol 121, 1817-1823.

Hermans E., Vanisberg M. A., Geurts M. and Maloteaux J. M. (1997) Down-regulation of neurotensin receptors after ligand-induced internalization in rat primary cultured neurons. Neurochem. Int. 31, 291-299.

Hermans E. and Maloteaux J. M. (1996) Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells. Biochem. Pharmacol 51, 1749-1752.

Gailly P., Hermans E. and Gillis J. M. (1996) Role of [Ca2+]i in "Ca2+ stores depletion-Ca2+ entry coupling' in fibroblasts expressing the rat neurotensin receptor. J Physiol 491 ( Pt 3), 635-646.

Hermans E., Octave J. N. and Maloteaux J. M. (1996) Interaction of the COOH-terminal domain of the neurotensin receptor with a G protein does not control the phospholipase C activation but is involved in the agonist-induced internalization. Mol Pharmacol 49, 365-372.

Hermans E., Gailly P., Gillis J. M., Octave J. N. and Maloteaux J. M. (1995) Lack of rapid desensitization of Ca2+ responses in transfected CHO cells expressing the rat neurotensin receptor despite agonist-induced internalization. J Neurochem. 64, 2518-2525.

Hermans E., Gailly P., Octave J. N. and Maloteaux J. M. (1994) Rapid desensitization of agonist-induced calcium mobilization in transfected PC12 cells expressing the rat neurotensin receptor. Biochem. Biophys. Res. Commun. 198, 400-407.

Hermans E., Octave J. N. and Maloteaux J. M. (1994) Receptor mediated internalization of neurotensin in transfected Chinese hamster ovary cells. Biochem. Pharmacol 47, 89-91.

Maloteaux J. M. and Hermans E. (1994) Agonist-induced muscarinic cholinergic receptor internalization, recycling and degradation in cultured neuronal cells. Cellular mechanisms and role in desensitization. Biochem. Pharmacol 47, 77-88.

Gailly P., Hermans E., Octave J. N. and Gillis J. M. (1993) Specific increase of genetic expression of parvalbumin in fast skeletal muscles of mdx mice. FEBS Lett. 326, 272-274.

Hermans E., Jeanjean A. P., Laduron P. M., Octave J. N. and Maloteaux J. M. (1993) Postnatal ontogeny of the rat brain neurotensin receptor mRNA. Neurosci Lett. 157, 45-48.

Hermans E., Jeanjean A. P., Fardin V., Pradier L., Garret C., Laduron P. M., Octave J. N. and Maloteaux J. M. (1993) Interaction of the substance P receptor antagonist RP 67580 with the rat brain NK1 receptor expressed in transfected CHO cells. Eur J Pharmacol 245, 43-50.

Moussaoui S. M., Hermans E., Mathieu A. M., Bonici B., Clerc F., Guinet F., Garret C. and Laduron P. M. (1992) Polyclonal antibodies against the rat NK1 receptor: characterization and localization in the spinal cord. Neuroreport 3, 1073-1076.

Hermans E., Maloteaux J. M. and Octave J. N. (1992) Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor. Brain Res. Mol Brain Res. 15, 332-338.